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Which is more effective dexmedetomidine or propofol?
Dexmedetomidine is a highly selective α2 -agonist that is associated with less respiratory depression and more cooperative behavior than propofol is. Dexmedetomidine also causes hypnosis, analgesia, sympatholysis, and inhibition of insulin secretion.
Is it safe to give dexmedetomidine to dogs?
Dexmedetomidine now has veterinary marketing authorization for use in dogs and cats in many countries. Dose rates, which are essentially half of those used with medetomidine, are given in terms of body surface area rather than as weight (as were originally those for medetomidine).
How does dexmedetomidine work in the human body?
Dexmedetomidine has two sites of action. It stimulates presynaptic α 2-adrenoceptors, thus inhibiting the release of norepinephrine and hence the propagation of pain signals. It also works postsynaptically to produce a decrease in blood pressure and heart rate.
Which is more potent clonidine or dexmedetomidine?
Dexmedetomidine (Precedex) is a relatively new α2 -adrenergic agent approved for short-term ICU use. Eight times as potent as its counterpart, clonidine, dexmedetomidine has excellent sympatholytic sedative and analgesic effects.
Last Update: Oct 2021
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